Spenkelink & Lewis labs
The Spenkelink & Lewis labs aim to develop new visual biochemistry tools to study dynamic biological processes, one at a time and with near-atomic resolution.
Our Research
DNA replication at roadblocks
We use cryo-EM and single-molecule imaging to reveal how human and bacterial replisomes overcome DNA damage and secondary DNA structures.
Mitochondrial DNA replication
We study how the mitochondrial replisome copies its genome and how disease-associated mutant proteins affect this process.
Single-molecule directed evolution
We develop methods for screening and selection at the single-molecule level to evolve new molecular functions with ultra-high sensitivity.
Fluorescent biosensors for diagnostics
We design customisable fluorescent biosensors for rapid, highly sensitive detection of specific biomolecules.
Latest News
Nick was invited to present his work on the development of a method to visualise the behaviour of DNA polymerases upon encountering a G-quadruplex.
Callum and Declan take home the trophy.
How do mitochondria replicate their DNA? We are excited to share that our lab has been awarded an ARC Discovery Project Grant to tackle this fundamental question! Postdoc & PhD opportunities coming soon!
Congratulations to Elise Wilkinson for presenting at the Sydney Protein Group Thompsion Prize Symposium.
