Spenkelink & Lewis Labs
Visualising biology, one molecule at a time
We develop new visual biochemistry tools to uncover the molecular mechanisms that drive dynamic biological processes, with near-atomic resolution.
Our Research
DNA replication at roadblocks
We use cryo-EM and single-molecule imaging to reveal how human and bacterial replisomes overcome DNA damage and secondary DNA structures.
Mitochondrial DNA replication
We study how the mitochondrial replisome copies its genome and how disease-associated mutant proteins affect this process.
Single-molecule directed evolution
We develop methods for screening and selection at the single-molecule level to evolve new molecular functions with ultra-high sensitivity.
Fluorescent biosensors for diagnostics
We design customisable fluorescent biosensors for rapid, highly sensitive detection of specific biomolecules.
Latest Papers
ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity
Nature Communications
·
2026
The interplay between supercoiling and DNA modifying enzymes at the single-molecule level
Scientific Reports
·
2026
